探讨动态动脉硬化指数和尿微量白蛋白与冠状动脉狭窄程度的相关性.docVIP

探讨动态动脉硬化指数和尿微量白蛋白与冠状动脉狭窄程度的相关性 　　摘要：目的：探讨动态动脉硬化指数（AASI）和尿微量白蛋白（MAU）与冠状动脉狭窄程度的相关性。方法：100例冠心病患者根据冠状动脉造影检查结果分为单支病变组（33例）、双支病变组（35例）、多支病变组（32例），同时设立正常对照组（30例）。测定和比较各组的AASI、MAU；以Gensini积分表示冠状动脉狭窄程度，评价Gensini积分与AASI、MAU的相关性。结果：多支病变组的AASI、MAU分别为0.7±0.1，（93.4±21.3）mg/L，双支病变组的AASI、MAU分别是0.6±0.2，（70.7±20.2）mg/L，单支病变组的AASI、MAU分别是0.4±0.1，（36.5±13.4）mg/L，均显著高于正常对照组（P0.05），各病变组之间两两比较，差异具有显著性（P0.05）。Gensini 积分与AASI 存在显著正相关（r=0.674，P0.01），与 MAU 存在显著正相关（r=0.732，P0.01）。结论：AASI和MAU 水平随冠脉病变支数的增加而上升，AASI 和MAU水平与冠状动脉狭窄程度具有显著的正相关。 　　关键词： 动态动脉硬化指数（AASI）；尿微量白蛋白（MAU）；冠状动脉狭窄；相关性 　　ABSTRACT：OBJECTIVE： To evaluate the relationship between Ambulatory Arterial Stiffness Index （AASI）， microalbuminuria （MAU） and the extent of coronary artery stenosis. METHODS： 100 cases of coronary heart disease patients were divided into single-vessel disease group （33 cases）， two-vessel disease group （35 cases） and multiple-vessel disease group （32 cases） according with the results of coronary arteriography. The normal control group （30 cases） was set up at the same time. Determine and compare the AASI， MAU of groups. The extent of coronary artery stenosis was signified with Gensini score. The relationship of AASI， MAU and Gensini score was evaluated. RESULTS： The AASI、MAU of multiple -vessel disease group were 0.7±0.1，（93.4±21.3）mg/L， respectively； the AASI、MAU of two-vessel disease group were 0.6±0.2，（70.7±20.2）mg/L， respectively； the AASI、MAU of single -vessel disease group were 0.4±0.1，（36.5±13.4）mg/L， respectively. The AASI、MAU of three disease groups were significantly higher than normal control group（P0.05）. Any two disease groups of them is statistically different（P0.05）. There were significant positive correlation between Gensini score and AASI， MAU（r=0.674， P0.01； r=0.732，P0.01）. CONCLUSION： The AASI、MAU levels increased with the increase of the coronary artery lesion counts and there were positive correlation between the extent of coronary artery stenosis and AASI、MAU levels. 　　KEYWORDS： Ambula