中西医结合诊疗方案治疗中青年2级高血压病的多中心随机对照试验.docxVIP

中国中西医结合杂志 2015 年 7 月第 35 卷第 7 期 CJITWM，July 2015，Vol． 35，No. 7·801·中西医结合诊疗方案治疗中青年 2 级高血压病的 多中心随机对照试验陈曦程广书范军铭摘要目的探讨中西医结合诊疗方案对中青年 2 级高血压病患者疗效及 24 小时动态血压的影响。方法 采取随机、安慰剂平行对照、多中心临床研究设计，将 199 例中青年 2 级高血压病患者随机分为治疗 组( 99 例) 和对照组( 100 例) 。两组均给予硝苯地平缓释片、氢氯噻嗪片为基础的联合降压治疗方案，在此 基础上治疗组给予联合降压宝系列中药治疗，对照组联合降压宝系列中药模拟剂治疗，均 0. 31 g / 片，每日2 次，每次 2 片，用药时间均为 8 周，并进行 24 周随访，比较两组 24 小时动态血压及偶测血压疗效，并进行安 全性评价。结果 与本组治疗前比较，治疗后两组日间、夜间偶测血压及 24 小时动态血压均明显改善 (P ＜ 0. 01) ; 治疗组治疗后夜间偶测收缩压及舒张压平均值下降水平优于对照组，差异有统计学意义 (P ＜ 0. 05) ; 两组治疗后日间偶测血压及动态血压疗效总有效率比较，差异均无统计学意义 (P ＞ 0. 05 ) 。结论 在硝苯地平缓释片及氢氯噻嗪片治疗基础上联合降压宝系列中药治疗中青年 2 级高血压病，可改善 夜间血压，尤其是夜间舒张压。关键词中西医结合诊疗方案; 24 小时动态血压; 中青年高血压病Treatment of Level 2 Hypertension by Diagnosis and Treatment Program of Integrative Medicine: a Multicentre， Ｒandomized Controlled Trial CHEN Xi，CHENG Guang-shu，and FAN Jun-ming Department of Hypertension ，Af-filiated Hospital ，Henan Institute of Traditional Chinese Medicine ，Zhengzhou (450004 )ABSTＲACTObjectiveTo explore the therapeutic effect of diagnosis and treatment program of integrative medicine( IM) on level 2 hypertension in the young and middle-aged patients and their ambulatory blood pressure． MethodsA random-ized，placebo parallel and controlled，multi-center clinical trial was performed． Totally 199 young and middle-aged level 2 hy-pertension patients were randomly assigned to the treatment group ( 99 cases) and the control group ( 100 cases) ． All received combined hypotensive treatment program by taking Nifedipine Sustained Ｒelease Tablet and Hydrochlorothiazide as basic drugs． Patients in the treatment group additionally took Western medicine ( WM) combined Jiangyabao serial drugs ( 0. 31 g per tab-let，2 tablets each time，twice daily) ，while those in the control group additionally took WM combined simulative agents of Jiangyabao serial drugs ( 0. 31 g per tablet，2 tablets each time，twice daily) ． The treatment course was 8 weeks for all，and24-week follow-ups performed． 24 h ambulatory blood pressure and casual blood pressure，a