儿童疱疹性咽峡炎应用炎琥宁联合利巴韦林治疗的效果观察.docVIP

儿童疱疹性咽峡炎应用炎琥宁联合利巴韦林治疗的效果观察 　　[摘要] 目的 探讨炎琥宁联合利巴韦林治疗儿童疱疹性咽峡炎的临床效果。 方法 选择本院104例儿童疱疹性咽峡炎患儿随机分为治疗组和对照组，治疗组在常规综合治疗的基础上给予炎琥宁联合利巴韦林治疗，对照组在常规综合治疗的基础上单用利巴韦林治疗，比较两组治疗效果。 结果 治疗组总有效率为98.1%，对照组总有效率为75.0%，治疗组总有效率明显高于对照组（P0.05）。 结论 炎琥宁联合利巴韦林治疗儿童疱疹性咽峡炎疗效显著，且无毒副作用，值得临床推广应用。 　　[关键词] 疱疹性咽峡炎；炎琥宁；利巴韦林 　　[中图分类号] R725.6 [文献标识码] A [文章编号] 1674-4721（2013）11（b）-0063-02 　　Efficacy observation of dehydroandrographolide succinate and ribavirin in treatment of children herpangina 　　TIAN Chun-hong WU Rong-chu 　　Dayong Hospital of Zhongshan City in Guangdong Province， Dayong 528476，China 　　[Abstract] Objective To study the clinical effect of dehydroandrographolide succinate and ribavirin in treatment of children herpangina. Methods 104 cases of children were randomly divided into treatment group and control group. On the basis of the routine comprehensive treatment， patients in treatment group were given dehydroandrographolide succinate and ribavirin treatment， while patients in control group were only given ribavirin treatment， the treatment effect of two groups was compared. Results The total effective rate of the treatment group was 98.1%， while it was 75.0% in the control group. Therefore the curative effect of the treatment group was significantly better than the control group （P0.05）. Conclusion The clinical effect of combination treatment of dehydroandrographolide succinate and ribavirin on children herpangina is good with no toxic side effects， is worthy of clinical popularization and application. 　　[Key words] Herpangina； Dehydroandrographolide succinate； Ribavirin 　　疱疹性咽峡炎是小儿急性上呼吸道感染中一种特殊的类型，是儿科多发病和常见病，主要由柯萨奇病毒引起，流感病毒及呼吸道合胞病毒等亦可导致发病[1]。疱疹主要在咽部和软腭，不累及齿龈和颊黏膜[2]，好发于夏秋季节。有文献提示[3]，近年来儿童疱疹性咽峡炎的发病率有明显上升趋势，具有感染性较强、传播较快及易反复发作等特点，如若不及时进行治疗，可导致慢性肾炎、风湿热等。近年来，本院对儿童疱疹性咽峡炎患者应用炎琥宁联合利巴韦林进行治疗，取得了较好疗效，现报道如下。 　　1 资料与方法 　　1.1 一般资料 　　选择2010年3月～2013年6月本院儿科收治的疱疹性咽峡炎患儿104例，全部患儿均符合《儿科学》第7版中关于疱疹性咽峡炎的诊断标准[4]，均有发热，体温38.5～40.5℃。将104例患儿随机分为治疗组和对照组，各52例。治疗组中，男29例，女23例；年龄6个月～6.5岁，平均（3.1±0.9）岁；病程0.5～2 d，平均（