参松养心胶囊治疗缓慢性心律失常疗效和安全性Meta的分析.docx

Efficacy and Safety of ShenSongYangXin capsule for SlowArrhythmia:a Meta-analysisSpeciality:Internal Medicine of Traditional Chinese MedicineAuthor:Tan TongTutor:Professor You KeAbstractObjective: To evaluate the clinical efficacy and safety of ShenSongYangXin capsuleon slow arrhythmia.Methods: We retrieved CNKI ,VIP, WANFANG, PubMed, the Cochrane Library ofclinical control trial databases and other databases by computer.According to theintegration and elimination standard of the literature,We chose the randomized controlledtrials (RCTs) of ShenSongYangXin capsule on slow arrhythmia.Two reviewers finished thequality assessment independently,extracted the data and cross checked. Then we used theRevMan 5.0 software for the Meta-analysis.Results: A total of 14 studies included 1121 cases of patients, the quality of itsresearch was low quality. Meta-analysis results showed that: compared with the controlgroup ,(1) 14 of the clinical efficacy of the efficiency of the combined effect of the test: ORcombined=5.06,95% CI was [3.75,6.84],Meta-analysis of results was statisticallysignificant(P 0.00001);(2)24h Holter efficacy in two studies the efficiency of thecombined effect of the amount of test: OR combined=6.72,95% CI was [2.85,15.86](P0.0001),24h Holter effect of ShenSong capsule was better than the control group;(3)6studies reported the average heart rate increase by comparing with the control group.Due tothe heterogeneity test,P 0.00001,I2=76%,so we chose the random effects model analysisand the results showed that:MD=7.10,95% CI was [5.47,8.73] (P 0.00001),the averageheart rate increase of ShenSongYangXin capsule was better than the control group;(4)Apart from the three studies,this systematic review in the studies reported adverse drugreactions.According to the studies,580 patients took ShenSongYangXin capsule.Eightstudies reported 13 cases of gastrointestinal reactions and we did not find significant sideeffects of ShenSongYangXin capsule.As a result of the lack of