肾脏功能指标检测及其在高血压肾病中的临床表达.docVIP

肾脏功能指标检测及其在高血压肾病中的临床表达 　　【摘要】目的 探讨血清胱抑素C（CysC）与传统肾功能检测指标在高血压肾病监测中的临床表达。方法 150例高血压肾病患者， 其中Ⅰ、Ⅱ、Ⅲ期各50例， 采用全自动化学法分别测定各期患者血清CysC、尿素（UR）、肌酐（SCR）含量， 并进行比较， 分析各指标在各期患者中的表达， 评价各指标在高血压肾病中的监测效能。结果 Ⅰ期高血压肾病患者CysC为（1.39±0.22）mg/L、UR为（9.86±1.52）mmol/L、SCR为（139.0±22.5）μmol/L， Ⅱ期高血压肾病患者CysC为（2.13±0.35）mg/L、UR为（10.07±1.71）mmol/L、SCR为（145.0±23.1）μmol/L， Ⅲ期高血压肾病患者CysC为（2.94±0.51）mg/L、UR为（10.71±2.06）mmol/L、SCR为（153.0±24.7）μmol/L。高血压肾病Ⅲ期患者CysC含量高于Ⅰ、Ⅱ期患者（P0.05）， Ⅰ期患者UR、SCR含量低于Ⅲ期患者（P0.05）。结论 高血压肾病患者存在不同程度的肾功能改变， 血清CysC测定较传统UR、SCR监测更能反映患者早期肾损伤。 　　【关键词】 高血压病； 肾病； 肾功能 　　DOI：10.14163/j.cnki.11-5547/r.2016.17.004 　　Clinical expression of renal function indicators detection in hypertensive nephropathy SHA Dan， DAI Mei， LIN Wen-tao. Hubei Xiantao City First People’s Hospital， Xiantao 433000， China 　　【Abstract】 Objective To investigate clinical expression of serum cystatin C （CysC） and renal function indicators in monitoring of hypertensive nephropathy. Methods A total of 150 hypertensive nephropathy patients， with 50 cases in each stages of Ⅰ， Ⅱ and Ⅲ， all received automatic chemical test to detect serum CysC， urea （UR）， and creatinine （SCR） contents for comparison. Expressions of indicators were analyzed， and their function in monitoring of hypertensive nephropathy was evaluated. Results Stage Ⅰ hypertensive nephropathy patients had CysC as （1.39±0.22）mg/L， UR as （9.86±1.52）mmol/L and SCR as （139.0±22.5）μmol/L. Stage Ⅱ hypertensive nephropathy patients had CysC as （2.13±0.35）mg/L， UR as （10.07±1.71）mmol/L and SCR as （145.0±23.1）μmol/L. Stage Ⅲ hypertensive nephropathy patients had CysC as （2.94±0.51）mg/L， UR as （10.71±2.06）mmol/L 　　and SCR as （153.0±24.7）μmol/L. Stage Ⅲ hypertensive nephropathy patients had higher CysC content than stages Ⅰ and Ⅱ patients （P0.05）， while stage Ⅰ cases had lower UR and SCR than stage Ⅲ cases （P0.05）. Conclusion Various renal function changes are shown in hypertensive nephropathy patients， and serum CysC can show better reflection of early renal injury in