血液白细胞分析在青中年精神分裂症患者中的临床意义.docVIP

血液白细胞分析在青中年精神分裂症患者中的临床意义 　　[摘要] 目的 分析血液白细胞在青中年精神分裂症患者中的临床意义，为隐性细菌性感染作为精神分裂症的始发原因寻找依据。 方法 选取2006年1月～2014年12月我院精神心理科住院的精神分裂症患者为病例组，并随机抽取体检中心体检的健康体检人群为对照组进行1∶1匹配的病例对照研究，应用统计描述、t检验、单因素条件性Logistic回归对数据进行统计分析。 结果 病例组和对照组分别收集了247例，病例组白细胞计数、中性粒细胞计数均高于对照组，差异有统计学意义（P0.05）；单因素条件性Logistic回归显示白细胞计数（OR=1.135，95%CI 1.035～1.245）、中性粒细胞（OR=1.197，95%CI 1.074～1.443）、中性粒细胞百分比（OR=4.653，95%CI 2.189～9.893）均是精神分裂症的高危因素。 结论 精神分裂症患者血液中白细胞水平较对照组高，血液白细胞水平增高是精神分裂症的高危因素，提示精神分裂症患者存在隐性细菌性感染的可能。 　　[关键词] 精神分裂症；隐性感染；白细胞；中性粒细胞 　　[中图分类号] R749.3 [文献标识码] A [文章编号] 1674-4721（2016）04（c）-0039-03 　　Clinical significance of white blood cells from blood in young and middle-aged patients with schizophrenia 　　LV Dong1 XIAN Jun-ding2 XIE Bo3 WEN Jin-feng4 YIN Ling5 CHEN Ming-yang2 YIN Jing-wen1 LIN Ju-da1▲ 　　1.Department of Psychiatric，Affiliated Hospital of Guangdong Medical College，Zhanjiang 524001，China；2.The Center for the Study of Life Quality and Applied Psychology，Institute of Humanities and Management，Guangdong Medical College，Dongguan 523808，China；3.Chronic Disease Prevention and Treatment Hospital of Nanshan District in Shenzhen City，Shenzhen 518000，China；4.Department of Psychology，Guangdong Three Nine Brain Hospital，Guangzhou 510510，China；5.Department of Psychology，the Third People′s Hospital of Jiangmen City in Guangdong Province，Jiangmen 529000，China 　　[Abstract] Objective To analyze the clinical significance of white blood cells from blood in young and middle-aged patients with schizophrenia，and look for the basis of recessive bacterial infections as an originatingreason of schizophrenia. Methods From January 2006 to December 2014，schizophrenic patients hospitalized in psychological department in our hospital were selected as case group，and cases of healthy people for physical examinations were randomly selected from physical examination center and classified into control group.The case control study in one to one matching was carried out，and these data were statistically analyzed by statis