血清25―羟维生素D及总IgE水平与儿童哮喘急性发作的严重程度的关系.docVIP

血清25―羟维生素D及总IgE水平与儿童哮喘急性发作的严重程度的关系 　　[摘要] 目的 探讨血清25-羟维生素D、总IgE水平与儿童哮喘急性发作严重程度的关系。 方法 收集2013年4月～2014年12月河北省承德市妇幼保健院儿科门、急诊及住院部收治的哮喘患儿98例为研究对象，根据患儿的临床症状、实验室检查结果及哮喘防控指南将其分为中重度组、轻度组和缓解组，同期健康幼儿30例为对照组。采用电化学发光法测定各组幼儿血清25-羟维生素D水平；采用免疫放射分析法测定血清总IgE水平。 结果 与对照组幼儿比较，三组不同患病程度的哮喘患儿血清25-羟维生素D水平均降低，而血清总IgE水平均升高，差异有统计学意义（P 0.05）；中重度组患儿血清25-羟维生素D与血清总IgE水平呈负相关（r = -7.28，P 0.05）。结论 哮喘患儿血清25-羟维生素D及总IgE水平与哮喘急性发作严重程度关系密切，为维生素D对于儿童哮喘的防治作用提供依据。 　　[关键词] 25-羟维生素D；血清总IgE；儿童；支气管哮喘；哮喘急性发作 　　[中图分类号] R725.6 [文献标识码] A [文章编号] 1674-4721（2016）10（b）-0063-04 　　[Abstract] Objective To explore the relationship between serum 25-hydroxy vitamin D， total IgE levels and asthma severity in children. Methods Ninety-eight children with asthmatic recruited from April 2013 to December 2014 in the Department of Out-patient， Pediatrics Emergency and In-patient of Maternal and Child Health-Care Hospital of Chengde were selected as the study objects， and they were divided into moderate and severe group， mild group and ease group based on clinical symptoms， laboratory test results and related asthma prevention and control guidelines， and 30 cases healthy children at the same period were selected as control group. The levels of serum 25-（OH） D of children were determined by electrochemical luminescence method and the serum total IgE （TIgE） levels were determined by immune radiometric analysis. Results Compared with the control， the serum level of 25-hydroxy vitamin D decreased but TIgE increased in the children with different severity of asthma （P 0.05）. There was negative correlation of 25-hydroxy serum vitamin D and TIgE in moderate and severe group （r = -7.28， P 0.05）. Conclusion Children have the lower 1evel of vitamin D who have severe asthma attacks. So the level of serum vitamin D can be taken as a condition assessment criteria for asthma attacks. That will be strong evidence for asthma management and prevention. 　　[Key words] 25-hydroxy vitamin D； Total IgE； Children； Asthma； Asthma symptom severity