1分子临床病理学-IHC.pdfVIP

For post-graduate program Clinical pathology-ZR-201509 分子病理学技术进展及临床应用 (第一部分) 周 韧 Prof., M.D., Ph.D. 浙江大学病理学与法医学研究所 浙江大学医学院病理学与病理生理学系 浙江大学司法鉴定中心 本章内容: 一、临床分子病理学方法1 二、当前分子病理学技术在临床的实际应用 三、分子病理学临床应用存在的问题及对策思考 来自临床的问题 Contemporary Understanding of Carcinogenesis by molecular biology as our introduction More than 100 years ago (1830), British physician Thomas Hodgkin discovered a type of Lymphoma with his naked eyes. In the time, obviously Thomas Hodgkin did never know R-S cells in his cases before the microscope available in clinic. While at present time, for us, what can be down with our naked eyes rather then with microscope or modern molecular techniques? ? The cellular elements in lymphoid hematopoietic tumors are the key to understand and diagnose their diseases. ? Even more, the molecules in the related cells are the key, especially involved in the development and differentiation of lymphoid hematopoietic cells ? That is the beginning of our story today. Understanding of Lymphocyte Development 1950s-2010 1. structure and function of lymphoid tissue Germenal Center(GC)：structure，function，transformation Thymus-depending zone Capsular and afferent lymphatics Reticulum supporting Cortex lymphatic tissue Subcapsular sinus Cortex Follicle