农药内分泌干扰效应研究进展.PDFVIP

DOI:10.7524/AJE.1673-5897.20160704001 方琪, 马彦博, 张思远, 等. 农药内分泌干扰效应研究进展[J]. 生态毒理学报, 2017, 12(1): Fang Q, Ma Y B, Zhang S Y, et al. Research progress in the endocrine disrupting effects of pesticides [J]. Asian Journal of Ecotoxicology, 2017, 12(1): (in Chinese) 农药内分泌干扰效应研究进展 方琪 1,2，马彦博 3，张思远 1，焦必宁 1,2, * 1. 西南大学柑桔研究所，重庆 400712 2. 农业部柑桔产品质量安全风险评估实验室（重庆），重庆 400712 3. 中国科学院重庆绿色智能技术研究院，重庆 400714 收稿日期：2016-07-04 录用日期：2016-08-22 摘要：农药作为农业生产过程中的一类重要生产资料，主要用作杀虫剂、杀菌剂和除草剂等。 由于农药的大量使用，目前在各类农产品及各种环境介质中都能被检测到，对饮食安全和环 境健康带来潜在危害。研究发现，许多农药为内分泌干扰物，其能够干扰人类和其它生物体 的内分泌系统正常功能。本文在总结国内外相关研究的基础上，对农药内分泌干扰效应的作 用机理及筛选模型进行总结，对有机氯、有机磷和拟除虫菊酯等各类农药的内分泌干扰效应 研究进展进行综述，并提出深入探究农药致毒作用机制和低剂量下多种农药联合毒性是本领 域的重要研究方向。 关键词：农药；内分泌干扰效应 Research Progress in Endocrine Disrupting Effects of Pesticides Fang Qi1,2, Ma Yanbo3, Zhang Siyuan1, Jiao Bining1,2* 1. Citrus Research Institute, Southwest University, Chongqing 400712, China 2. Laboratory of Quality and Safety Risk Assessment for Citrus Products, Ministry of Agriculture, Chongqing 400712, China 3. Chongqing Institute of Green and Intelligent Technology, Chinese Academy of Sciences, Chongqing 400714, China. Received 4 July 2016 accepted 22 August 2016 * 基金项目：中央高校基本科研业务费专项资金项目(XDJK2015C088, SWU115026)；2016年国家农产品质量安全风险评估重大专 项(GJFP2016004, GJFP2016014)；国家现代农业柑橘产业技术体系建设专项（CARS-27） 作者简介：方琪(1987-)，女，助理研究员，研究方向为环境毒理学，E-mail: fangqi@cric.cn * 通讯作者(Corresponding author)，E-mail: jiaobining@cric.cn Abstract: Pesticides are widely used as insecticides, fungicides and herbicides in the process of agricultural production, and have been detected in all kinds of agriculture products and environment，which bring potential risk to food safety and environmental health. It is reported that many pesticides have been identified as endocrine disruptors, which could alter the normal functioning of the endocrine system of both wildlife and humans. This paper reviews the potential mechani