坦索罗辛和硝苯地平在输尿管下段结石辅助排石中作用的比较.pdfVIP

6l2 中华泌尿外科 壶 生!旦箜 !鲞筮 塑 ! ! ! 竺 !!旦 坦索罗辛和硝苯地平在输尿管下段结石 辅助排石中作用的比较 吕家驹 尉立京 张辉 丁森泰 丁克家 【摘要】 目的 分析比较坦索罗辛和硝苯地平在输尿管下段结石辅助排石中的疗效。 方法 180例输尿管下段结石患者随机分3组 ，每组 60例。结石直径 0．4～1．0 cm。组 1为对照组，未给予 输尿管平滑肌松弛剂；组2给予硝苯地平 10 mg，3次／d；组3给予坦索罗辛0．4 mg，1次／d。每例患者 治疗观察期不超过2周。 结果 2周内结石排出者组 1为26例(43．3％)，组2为 44例(73．3％)， 组 3为 49例(81．7％)，组2、3与组 1比较排石率差异有统计学意义(P0．05)。平均排石时间组 1～3分别为9、8、4 d，组 1与组3比较差异有统计学意义(P0．05)，组 2与组 3比较差异无统计学意 义(P0．05)。2周内组 1～3因再次发生肾绞痛而需镇痛治疗者分别为5例(8．3％)、1例(1．7％) 和0例，组间比较差异有统计学意义(P0．05)。2周内3组均未出现明显副作用 ，无因不能耐受而 退出者。 结论 坦索罗辛和硝苯地平在输尿管下段结石辅助排石方面安全、有效，能明显提高排石 率。 【关键词】 输尿管结石； 坦索罗辛 ； 硝苯地平 Comparison of tamsulosin versus nifedipine for the management of lower ureteral stones LU Jia—ju． WEI Liqing，ZHANG Hui，DING Sen—tai，DING Ke-jia．Department of Urology，Shandong Provincial Hospi— tal，Shandong University，Jinan 250021，China Corresponding author：LU Jia l，kyoto2310@sina．corn 【Abstract】 Objective To compare the eficacy of tamsulosin and nifedipine for the adjunctive expulsive therapy in patients with lower ureteral stones． M ethods A total of 1 80 patients with stones (0，4—1，0 cm in diameter)located in the lower ureter(juxtavesical or intramural tract)were randomly divided into 3 groups(60 cases in each group)．Group 1 served as controls；group 2 received nifedipine (10mg，3 times daily)；and group 3 received tamsulosin(0．4 mg，once daily)．All patients were observed for 2 weeks． Results During 2 weeks，expulsion of stones was observed in 26 cases(43．3％ )of group 1，in 44(73．3％ )of group 2，and 49 (81．7％)of group 3．The difference in expulsion rates between groups 2，3 and group 1 was statistically significant(P0．05)．The mean expulsion time of groups 1．2 and 3 was 9，8 and 4 d，respectively，with signifcant diference between groups 1 and 3(P0．05)，but no signifcant diference between groups 2 and 3(P0．05)．In groups 1，2 and 3，renal colic recu~ed within 2 weeks and analgesics were used in 5 cases(8．3％)，1(1．7％)and 0，respectively．with signif． cant difference between the groups(P0．05)． Al the patients tolerated