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Assessment of Exhaled Breath Condensate pH in
Assessment of Exhaled Breath Condensate pH in
Exacerbations of Asthma and Chronic Obstructive
Pulmonary Disease
A Longitudinal Study
Balazs Antus1,2, Imre Barta1, Tamas Kullmann1, Zsofia Lazar3, Marta Valyon4, Ildiko Horvath3, and Eszter Csiszer2
1Department of Pathophysiology, 2Department of Pulmonology, and 4Department of Clinical Chemistry, National Koranyi Institute of TB and
Pulmonology, Budapest, Hungary; and 3Semmelweis University, Department of Pulmonology, Budapest, Hungary
Rationale: Exhaled breath condensate pH has been proposed as
a noninvasive marker of airway inflammation. However, due to
standardization difficulties in pH measurement techniques, differ-
ent pH readings were obtained in previous studies.
Objectives: In this longitudinal study we assessed condensate pH in
patients with an exacerbation of asthma or chronic obstructive
airway disease using the very precise carbon dioxide standardization
method that negates the effect of this gas on condensate acidity.
Methods: Condensate pH, fractional exhaled nitric oxide, lung
function, and blood gasesweremeasured in 20 nonsmoking patients
with asthma and 21 smoking and 17 ex-smoking patients with
chronic obstructive airway disease first at hospital admission due
to an acute exacerbation of the disease and again at discharge after
treatment. Condensate pH was also assessed in 18 smoking and 18
nonsmoking healthy control subjects.
Measurements and Main Results: In patients with asthma, condensate
pHwassignificantlydecreasedat the timeofexacerbationcompared
with nonsmoking control subjects and increased with treatment. In
patients with chronic obstructive airway disease, condensate pH
remained unchanged during exacerbation, both in smokers and ex-
smokers. Nevertheless, condensates collected from smokers were
more acidic than those of ex-smokers. A similar difference was
observed between smoker and nonsmoker healthy control subjects.
No correlations were found between condensate pH and fractional
exhaled
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