Stomach-screen complex stress-induced gastric mucosal damage in rats protective effect of morphology.docVIP

 PAGE \* MERGEFORMAT 13 ‘Stomach-screen complex’ stress-induced gastric mucosal damage in rats protective effect of morphology Author: Zhang Xiao-liang, Li Chang-qing, Yan Xiu, Xie Yongen, Shen Yi, Dan-Dan Huang, Lin [Abstract] Objective To hyaluronic acid as a substrate, developing a more protective effect on gastric mucosal barrier of the new agents, and explore the protective effect of hyaluronic acid on the mucous membrane to expand the scope of application of new hyaluronic acid. Methods Wistar rats with acute hemorrhagic stress-induced gastric mucosal injury in animal models of erosion, development of gastric mucosal injury grading standards and research to determine the effectiveness of the standard preparations. Experimental animals before the experiment gavage study preparation 3ml, the control group fed normal saline. At the same time the establishment of model group validation model. Animals were killed 24h after the appearance of gastric mucosa morphological changes observed; slices observed histopathological changes in gastric mucosa. Results The mucosal appearance of good, no significant mucosal erosion and hemorrhage; control group were seen scattered in the bleeding point and the destruction of mucosal integrity; model control group, a totally wide range of stomach bleeding, mucous membrane covering the surface of a large number of blood clot. Experimental group was 90%; the control group response rate was 22%. Statistical test, P amp;lt;0.05. Conclusion The results showed that ‘stomach-screen complex’ of stress-induced gastric mucosal injury has obvious protective effect. This shows that hyaluronic acid can replace gastric mucosal barrier glycoprotein substrate and has important application value for development. [Keywords:] hyaluronic acid; preparation; morphological observation; animal model Preparation of protecting gastromucosa and observation its effect on protecting of acute stress gastromucosa damage in rats [Abstract] Objecti