A family of acute myeloid leukemia related gene ELF2C bioinformatics analysis.docVIP

 PAGE \* MERGEFORMAT 15 A family of acute myeloid leukemia related gene ELF2C bioinformatics analysis Of: Wang Chengyi, Wang few yuan, Zhang Yiwen, Li Jing Kong [Abstract] Objective Bioinformatics of the new clones in familial acute myeloid leukemia related gene ELF2C and its protein sequence analysis, to explore its function. Ways to the human genome database based on the use of bioinformatics programs to predict ELF2C The gene structure, chromosomal localization, physical and chemical properties of proteins encoded, subcellular localization, protein functional domains and so on. Results ELF2C gene is located on 4q31.1, full-length 2 257 bp, containing 432 bp open reading frame, encoding 143 amino acids protein, and the encoded protein is localized in the nucleus, with multiple modification sites and functional motifs, is a function of active proteins. Conclusions ELF2C gene may be in the family of the development of acute myeloid leukemia has a biological function of a full-length new genes. [Keywords:] pedigree, leukemia, myelocytic, acute, genetic, computational biology, sequence analysis, DNA Search for familial acute myeloid leukemia-specific genes, the author of suppression subtractive hybridization (suppression subtractive hybridization, SSH) was constructed in familial acute myeloid leukemia by suppression subtractive cDNA library to one of the familial acute myeloid leukemia differentially expressed genes representative of the new EST (zywb4 fragment-based [1], integrated applications such as e-SMART RACE cloning and molecular biology techniques, from familial acute myeloid leukemia bone marrow specimens from cloned its full length cDNA, named ELF2C (GenBank accession number: DQ359746) [2]. ELF2C to further explore the genetic structure and biological function, the author Bioinformatics analysis of the preliminary analysis of ELF2C gene, reported as follows. 1 Materials and methods 1.1 Materials 1.1.1 A sample of bone marrow sampl