Advances in medicine of liver fibrosis.docVIP

 PAGE \* MERGEFORMAT 19 Advances in medicine of liver fibrosis Keywords:] liver fibrosis, Chinese medicine, traditional Chinese medicine, review Viral hepatitis, alcohol and chemical factors such as long-term toxic liver damage, leading to chronic inflammation activity, after the repair of injured liver cells, the formation of varying degrees of hepatic fibrosis (hepatic fibrosis, HF). HF is a fiber proliferation and degradation balance, fiber excessive deposition in the liver tissue results. study confirmed that hepatic stellate cells (HSC) in hepatic fibrosis play a key role in the development of effective intervention in the biological behavior of HSC is able to successfully control HF. The most effective anti-HF is positive and effective measures to eradicate or control the origin of chronic liver disease factors, the primary disease is essentially an effective treatment to prevent the extracellular matrix (ECM) deposition, or to promote its degradation. HF is the development of chronic hepatitis to cirrhosis of the necessary step . The latest study found, HF and even cirrhosis is reversible, thereby promoting hepatic fibrosis drug research [1-2]. the ideal anti-HF medications should have for decades, well tolerated, of liver-specific target effects, non-toxic or low toxicity. In recent years, domestic and international studies have shown Chinese herbal anti-HF has broad application prospects. author of herbs and their compound resistance to HF for a brief overview of recent research. 1 active ingredient 1.1 saikosaponin Saikosaponin (saikosaponins, SS) is the root of Umbelliferae Bupleurum extract the active ingredients. HSC activation is the central link of HF occurs, this process occurs, the development of a variety of cells, cytokines (soluble media ), ECM (insoluble medium) and non-peptide medium (ethanol, reactive oxygen species, etc.) involved. Therefore, the current control HF, the key is for and HSC activation-related sectors, mainly