Advances in breast cancer anti-angiogenesis_0.docVIP

 PAGE \* MERGEFORMAT 16 Advances in breast cancer anti-angiogenesis [Keywords:] breast cancer; angiogenesis; anti-angiogenesis; VEGF Breast cancer is one of the most common malignancy of women in recent years, the incidence is rising, and there are getting younger and younger age of onset [1]. As early breast cancer can occur in lymphatic and hematogenous metastasis, so breast cancer with particular emphasis on integrated .20 Treatment of the early 70 century, Folkman [2] and put forward the tumor growth and metastasis depend on angiogenesis theory, the anti-angiogenic tumor biological targeting therapy has become the main direction of research, has become important to improve the cure rate of breast cancer one of the ways. In this paper, anti-angiogenesis in breast cancer research advances are summarized below. 1 basic research of tumor angiogenesis 1.1 The theory of tumor angiogenesis tumor angiogenesis (tumor angiogenesis) is the growth of tumor cells and tumor-induced microvascular microenvironment created in the process of blood circulation, tumor growth, invasion and metastasis has an important role [3] .1971 years Flo kman proposed tumor growth depends on angiogenesis, stimulation of angiogenesis-related factor signal transduction, leading to vascular endothelial cells from relatively static to rapid growth [2] In 1996 Hanahan and Folkma [4] proposed the concept of angiogenic switch, explained solid tumor growth, metastasis and angiogenesis relationship. They will be divided into two phases of tumor growth: (1) early vascular: also known as avascular stage, tumor diameter less than 1 ~ 2mm, the role and the surrounding tissue by diffusion of gases and material exchange. Without neovascularization, tumor cells in a dormant state or the occurrence of degradation; (2) the blood vessels of: tumor diameter of more than 2 ~ 3mm, need to rely on the tumor vascular oxygen supply, access to nutrition and excretion of waste. this stage a large numbe