Chinese alkaloids pharmacokinetics and Thinking Research.docVIP

 PAGE \* MERGEFORMAT 21 Chinese alkaloids pharmacokinetics and Thinking Research Of: Liu Lili, Liu Xiao-han, Chen Lihua, Zhu Weifeng, licensing Min, Yi Wen Jiao, Zhao Yi [Abstract] Chinese home and abroad in recent years alkaloids pharmacokinetics of literature retrieval, and analyzed and summarized to introduce the method of its determination in the body, and the alkaloid monomer, the effective part and the pharmacokinetics of compound study the situation, noting that the alkaloids future pharmacokinetic studies need to focus on the issue. [Keywords:] alkaloids; analysis; pharmacokinetics Abstract: To retrieve, analyze and summarize the literatures on the pharmacokinetic study of alkaloid compounds at home and abroad in recent years and to introduce the analytical method in vivo, the processes of the pharmacokinetics of active alkaloids, extract and prescription. At the same time the problem which needs to pay attention to for the future pharmacokinetic studies or alkaloid compounds was pointed out. Keywords:: Alkaloid; Analytical method; Pharmacokinetic Alkaloid widely in plant kingdom, such as ephedra, Fritillaria, berberine, and so mainly contains alkaloids aconitine, there are many clinical applications. Alkaloid structurally diverse, experimental proof of their broad physiological and pharmacological activity including anti-bacterial anti-inflammatory, cough and asthma, malaria, anti-arrhythmia, cancer, etc., the compounds of the domestic and international medical research has become a hot topic. In recent years, with high sensitivity and specificity testing technology, alkaloids pharmacokinetics further revealed that the alkaloid drug screening and clinical applications of the data. now alkaloids in recent years, pharmacokinetic study progress are summarized below. An analysis of biological samples Alkaloid compounds in pharmacokinetic studies, to alkaloids in biological samples and its metabolites for quantitative analysis. First