Dexamethasone Sodium Phosphate Preparation of thermosensitive gel.docVIP

 PAGE \* MERGEFORMAT 20 Dexamethasone Sodium Phosphate Preparation of thermosensitive gel [Abstract] Objective To design and preparation of dexamethasone sodium phosphate (dexamethasone sodium phosphate, DSP) temperature-sensitive in situ gel for local application of foundation. Preferred method of prescriptions, examine a variety of additives on the gelation temperature of the impact of regulation in order to obtain optimum substrate concentration gelation temperature. Using differential scanning calorimetry (DSC) study the thermal effect of gelation process. The findings have confirmed by poloxamer 407 as a substrate prepared by temperature-sensitive gel DSP, optimized Prescription: The quality score was 14.1% Poloxamer 407,0.2% of the hyaluronic acid, 10% glycerol, 15% of the propylene glycol and 2% of the DSP. DSC measurement obtaining the gel temperature of 26 ℃ , and the gelation process of thermal effects is very low, enthalpy value of 0.032 J * g-1 * K-1. Conclusion DSP prepared gel at room temperature for temperature-sensitive fluid in the body temperature can occur under the conditions of phase turned into a gel, it is worth further development and research. [Keywords:] temperature-sensitive in situ gel; dexamethasone sodium phosphate; Poloxamer 407 Abstract: Objective To design and prepare dexamethasone sodium phosphate (DSP)  loaded thermosensitive in situ gel, and provide scientific information for clinical application.Methods Selection of different materials and their influence on gelation temperature (GT), were evaluated.Different GT could be obtained by adjusting the concentration of poloxamer 407.Heating curve of gelation process was investigated by employing differential scanning calorimetery (DSC). Results Poloxamer 407 was adopted as gel base to prepare DSP gel.The optimized formulation was composed of 14.1% poloxamer 407,0.2 % hyaluronic acid, 10% glycerin, 15% propylene glycol and 2% DSP.GT of the formulation was 26 ℃ by DSC.And th