Donor lymphocyte infusion-induced GVL effect of the treatment of leukemia complicated with liver GVHD.docVIP

 PAGE \* MERGEFORMAT 7 Donor lymphocyte infusion-induced GVL effect of the treatment of leukemia complicated with liver GVHD Author: Li Xin-Yan, Mao-Ping, Li Shan, Zhu Zhigang, Mo Jian, Zhang Yuping [Abstract] Objective To investigate the non-myeloablative hematopoietic stem cell transplantation followed by donor lymphocyte infusion for the treatment of acute leukemia. Methods one cases of acute unclassified leukemia, for non-myeloablative hematopoietic stem cell transplantation. Conditioning regimen: busulfan 8mg/kg, cyclophosphamide 120mg/kg, anti-thymocyte globulin (ATG) 25mg/kg. Graft-versus-host disease (GVHD) prevention: cyclosporine A joint short-term methotrexate. In access to hematopoietic stem cells implantation, the formation of mixed chimerism (MC), after +53 days +98 days +125 days, +152 days, 182 days, OK after G-CSF mobilized donor lymphocyte infusion (DLI). The results of transplantation of early formation of MC state, to achieve hematologic partial remission, no acute GVHD occurred. +102 Days into a blood donor type; the 5th DLI and obtained complete remission and hematological complete donor chimerism, concurrent performance of liver function damage of chronic GVHD. Conclusion Non-myeloablative hematopoietic stem cell transplantation for acute leukemia Across DLI, complete donor chimerism available and hematological complete remission, but should pay attention to post-DLI chronic GVHD. [Keywords:] hematopoietic stem cell transplantation; non-myeloablative; donor lymphocyte infusion; acute leukemia; graft-versus-leukemia effect; graft-versus-host disease [Abstract] Objective To explore clinical curative effect of donor lymphocyte infusion followed by non-myeloablative haemotopoietic stem cell transplantation for acute leukemia.Methods One patient with unclssified acute leukemia was performed allogeneic haematopoietic stem cell transplantation with non-myeloablative conditioning regimen consisting of anti - themocyte globulin (25mg/kg),