Drug Targeting of gene expression regulation of ID4 Bioinformatic prediction and analysis of.docVIP

 PAGE \* MERGEFORMAT 18 Drug Targeting of gene expression regulation of ID4 Bioinformatic prediction and analysis of Author: Lu Xue-Chun, Chi Xiao-hua, Lou Fangding, Zhu Hongli, Hui Fan, Su-Xia Li, Yu Li Abstract ID4 gene closely related to the low expression of tumor, its high expression has a clear anti-leukemia effect, but no expression in leukemia cells. The preliminary study by bioinformatics analysis of ID4 gene promoter structure, prediction of gene expression regulation of ID4 cis-elements and related drugs are targeted for screening of gene expression regulation of ID4 prerequisite for the creation of drugs. To the human genome databases and computer Internet as a platform to catch to take ID4 gene 5 ‘flanking region of 3 000 bp non-coding DNA sequences and mRNA sequences in the ORF sequence; the use of TESS and Genomax analysis software and other online promoter of human transcription factor database search that may exist in cis-structure; the use of SAGE and the GEO databases affect the ID4 gene expression analysis of related factors. The results showed that: ID4 genes II promoter in the 5’-untranslated region of -45 bp Office has a typical TATA box. 1 300 bp in length of the ID4 promoter region, there are multiple cis-structure, including Sp1, c  Myb, abaA, C / EBPalpha, GR, ERE, and Zeste may have a positive regulatory role; CCAAT  binding factor, GCF, WT1  KTS, HiNF  C and EGR2 regulation may have a negative effect. Conclusions: ID4 gene expression may be affected by glucocorticoid, estrogen, thyroid hormone and follicle-stimulating hormone regulation of a variety of active substances. Keywords: ID4 gene leukemia with dexamethasone follicle-stimulating hormone, estrogen bioinformatic analysis Bioinformatics Scan Analysis for Predicting Drug Targeted Modulation on ID4 Gene Expression Abstract Low expression of ID4 gene is tightly related with carcinogenesis and high expression shows a definite anti  leukemia eff