Effects of losartan on rats with renal protective effect.docVIP

 PAGE \* MERGEFORMAT 12 Effects of losartan on rats with renal protective effect [Abstract] Objective To investigate the effect of losartan valsartan on renal protective effect and mechanism. Methods 48 Wistar rats were randomly divided into control group, renal failure group, losartan group, 16 rats in each. Renal failure group and losartan group intraperitoneal injection of doxorubicin 4 mg / kg, 1 time per week, continuous 5 w, making adriamycin rat model; control group was injected with normal saline the same way. copy the successful model of chlorine losartan losartan group were given 1.2 mg / only gavage, 1 / d; renal failure group was given an equal volume of normal saline, 1 time / d, are continuous administration of 2 w. 24 h blood biochemical assay urea nitrogen (BUN), creatinine (Cr), colorimetric detection of renal cortical malondialdehyde (MDA), superoxide dismutase (SOD), RT PCR method for detection of kidney AT1, AT2, ACE and AGT mRNA expression. Results Compared with control group, renal failure, serum BUN, Cr were significantly increased in the renal cortex increased MDA, SOD decreased (P lt;0.05); losartan group compared with the renal failure group, serum BUN, Cr were decreased significantly, reduced MDA in renal cortex, SOD increased (P lt;0.05). and the control group, renal failure, renal AT1 expression increased group, AT2 lower, AGT and ACE levels increased (P lt;0.05); losartan group transfer down for the AT1, AT2 expression levels close to the control group, AGT lower level, ACE levels decreased but still higher levels (P lt;0.05). Conclusion Losartan rats with adriamycin with delayed renal insufficiency progress in reducing oxidative stress injury. [Keywords:] Losartan; doxorubicin; renin-angiotensin system (RAS); renal function [Abstract] Objective To investigate the protecting effect of Losartan on the kidney of the rats with uninephrectomized adriamycin induced nephrosis and study its possible mechanisms. Methods Experiment