Effects of naloxone on oxytocin influence memory impairment in mice.docVIP

 PAGE \* MERGEFORMAT 11 Effects of naloxone on oxytocin influence memory impairment in mice On: Sun Bin, Zhu Fang, HEILONGJIANG ADMINISTRATIVE CADRE, Si-Peng, Liang Jian, Zhang Yongmei [Abstract] Objective To observe the lateral ventricle were given naloxone, oxytocin (oxytocin, OT) on learning and memory and impact of opioid receptors in the OT role in learning and memory in mice. Methods by stratified block design will then mice were divided into 4 groups (n = 7): saline group (NS group), naloxone group (Nal group), OT group, Nal + OT group. using passive avoidance test were measured after administration of 1 day, 2 days incubation period in mice and the number of errors. Results 2 days after treatment, compared with the NS, OT group increased the number of errors (P lt;0.01), latency (P lt;0.05); with the OT group: Nal + OT group, the number of errors decreased (P lt;0.05), latency difference was not statistically significant (Pgt; 0.05). Conclusion In this experimental conditions, the ICV microinjection of OT can damage the memory function in mice, and intracerebroventricular opioids given by antagonist naloxone, the reversal of OT-induced memory impairment, suggesting that damage to the memory of the role of OT with the opioid receptors. [Keywords:] oxytocin; naloxone; passive avoidance test; Memory Abstract: Objective To investigate the effect of naloxone or oxytocin (OT) microinjection into lateral cerebral ventricle on the memory in mice, and to explore the role of opioid receptor in the effect of OT on memory in mice. Methods The mice were randomly divided into 4 groups (n = 7 each): normal saline group (NS group), naloxone Nal group, OT group, Nal + OT group. The times of the errors and the duration of latency were respectively recorded on the first day and the second day after the drug administration in step-through task. Results On the second day, as compared to the NS group, the times of errors increased (P lt;0.01) and the duration of