Effects of propofol on acute autologous blood clot pulmonary embolism protection.docVIP

 PAGE \* MERGEFORMAT 12 Effects of propofol on acute autologous blood clot pulmonary embolism protection Of: Howard government Suchun Yong Ma Xiaogang [Abstract] Objective To observe the effects of propofol on acute autologous blood clot and pulmonary embolism in rats and its mechanism. Autologous blood clots were prepared with acute pulmonary embolism model, rats were divided into normal control group, model group, propofol low, medium and high dose group (4,8,16 mg kg-1 h-1). for blood gas analysis, lung coefficient, lung tissue malondialdehyde (MDA content and superoxide dismutase (SOD activity in blood measured by radioimmunoassay endothelin (ET 1, thromboxane 2 (TXB2 contents, RT PCR and Western blot detection of lung surfactant protein A (SP AmRNA and protein expression. Results of propofol can increase blood oxygen, blood carbon dioxide pressure level, SOD activity, SP A mRNA and protein expression, decreased lung index, MDA, ET 1, TXB2 content. Conclusions of propofol on acute pulmonary embolism has a protective effect in rats. [Keywords:] propofol, pulmonary embolism, pulmonary surfactant protein A Misdiagnosis of acute pulmonary embolism is a very high mortality rate and disease, and increase with age, higher morbidity and mortality (1). Propofol is a relatively new intravenous anesthetic drugs, anesthetic effect in the play at the same time, because of its infusion, may have different effects on body tissue. has been shown that propofol has a protective effect on acute pulmonary embolism (2), autologous blood clots in acute pulmonary embolism in the role of small, but autologous blood clot formation and thrombosis of clinical pulmonary embolism has some similarities to more truly reflect the changes in the pathophysiology of disease, this paper autologous blood clot through the rat model of acute pulmonary embolism in acute pulmonary embolism with propofol The role and to explore its mechanism. 1 Materials and methods 1.1 Material