Effects of metformin on impaired glucose tolerance Influence of homocysteine.docVIP

 PAGE \* MERGEFORMAT 16 Effects of metformin on impaired glucose tolerance Influence of homocysteine 【Abstract】 by detecting the effects of metformin on impaired glucose tolerance (IGT) in patients with plasma homocysteine, vitamin B6, vitamin B12, folic acid level changes, and explore the IGT in patients with metformin on plasma homocysteine levels in the results of plasma total homocysteine level and BMI, WL, FBG, PBG, DBP, TG and other indicators related to the short-term metformin treatment of IGT by the plasma of patients with vitamin B6, vitamin B12 gradually declining, folic acid is not affected, but a gradual increase in total plasma increased homocysteine. 【Key Words】 metformin; impaired glucose tolerance; homocysteine; vitamin B6; Vitamin B12; folic acid 【Abstract】 This research now give an observation study and pass examination metformin treated in impaired glucose toleranc (IGT) sufferer’s blood plasma homocyseine, vitamin B6, vitamin B12, folic acid level variety circumstance, to study the effect of metformin on the IGT sufferer’s blood plasma homocysteine level. The blood plasma homocysteine level related to BMI, WL, FBG, PBG, DBP, TG, etc. Through short term treatment of metformin in IGT, plasma vitamin B6, the vitamin B12 gradually descended, the folic acid was uninfluenced, blood plasma total homocysteine climed. 【Keywords:】 metformin; impaired glucose tolerance; homocystein; Vitamin B6; Vitamin B12; folic acid; Reported cases of the disease are caused by metformin in the treatment of B vitamins and folic acid malabsorption adverse reactions [1], while vitamin B6, vitamin B12 and folic acid is the metabolic pathway of homocysteine in the coenzymes and cofactors, it may be metformin lead to high plasma hyperhomocysteinemia increase the risk of diabetic vascular complications. This study was detection of metformin treatment of type 2 diabetes, impaired glucose tolerance pre-(IGT) in patients with plasma homocys