Extraction of membrane separation technology of antibiotics FKR1565.docVIP

 PAGE \* MERGEFORMAT 9 Extraction of membrane separation technology of antibiotics FKR1565 Author: Mei Ying Tung Lan-Lin Mian Wenjian Bo Zheng Bo Zheng Xiaoxian [Abstract] The polyethersulfone ultrafiltration membranes and polyamide nanofiltration membrane technology, combined with frame filtering and resin elution by means of nucleoside antibiotics FKR1565 extraction separation of the experimental results show that the use of ultrafiltration and nanofiltration technology can remove impurities and concentrated resin eluate to avoid the heat during the vacuum concentration FKR1565 decomposition. [Keywords:] antibiotics FKR1565; ultrafiltration; nanofiltration; concentration; extraction Membrane technology is a modern and efficient separation technique with high efficiency, energy saving, process easy to control, easy operation, less pollution, easy to integrate with other technologies, etc., have been on antibiotics (such as erythromycin, oxytetracycline, tetracycline, spiramycin, penicillin, 6APA, etc.) are applied on the production of [1 ~ 4]. The author FKR1565 antibiotics used in the pilot production of ultrafiltration and nanofiltration technology combined with the new technology of the extraction and separation, to achieve the desired effect, the results will now be reported as follows. FKR1565 for the water-soluble anti-tumor antibiotics, molecular weight of about 300, the stability is poor, acid, alkali, especially very unstable to heat the crude extract of the original production process as follows: fermentation liquid filtration (to the residue), the clear liquid through the ion-exchange resin adsorption, dilute ammonia elution, eluate vacuum concentration (40 ℃ below), with crude extract. The process in operation, there are two drawbacks: First, the filtered supernatants large amount of resin adsorption a long time, while there are still clear liquid pigment, protein and other impurities, were not dealt with directly by ion exchange resin adsor