Fas - FasL and tumor related Research progress.docVIP

 PAGE \* MERGEFORMAT 11 Fas / FasL and tumor related Research progress [Keywords:] Fas / Fasl protein; liver Is an important cell surface Fas death receptor, signaling molecules of apoptosis. Fas and its ligand FasL binding, activation and apoptosis signal transduction, thereby inducing apoptosis. Tumor cells through Fas-mediated apoptosis resistance and back to T cell apoptosis in immune cells, the tumor cells to evade immune surveillance to survive. In recent years, scholars at home and abroad Fas / FasL system and immune escape mechanisms of the liver and the corresponding countermeasures are in-depth study and discussion Progress in this area now reviewed. 1 Fas / FasL system Fas, also known as Apo-1 or CD 95 molecules, it is widely distributed in a variety of cell surface transmembrane glycoprotein, such as activated T, B lymphocytes, monocytes, fibroblasts, endothelial cells, biliary cells , mesangial cells and endometrial cells, etc.. Fas molecule and tumor necrosis factor (TNF) receptor and nerve growth factor (NGF) receptor homology, belong to TNF and NGF receptor superfamily 353.sFas known as soluble Fas, free in the blood, cells and other extracellular fluid, which is Fas gene transcription and translation process due to missing part of the base. sFas lack transmembrane protein, it can not be combined with the induction of FasL apoptosis. but it can be competitive binding with Fas FasL, leading to immune suppression, tumor cells which is a mechanism to evade the immune system. Fas FasL in the human body is the natural ligand, TNF family are type transmembrane protein. FasL was mainly expressed in activated T cells, N K cells, some tumor cells and some immune privilege of areas such as the anterior chamber, testicular trophoblastic surface. membrane-bound FasL cleaved under the action of the metal as soluble FasL (sFasL), its ability to mediate apoptosis in less than membrane-bound. 2 Fas / FasL-mediated apoptosis process Fas and