Fcα R1 gene 5 end of regulation and the UTR District SNPs and haplotypes in South China Han prognosis in patients with IgA nephropathy.docVIP

 PAGE \* MERGEFORMAT 8 Fcα R1 gene 5 ‘end of regulation and the UTR District SNPs and haplotypes in South China Han prognosis in patients with IgA nephropathy Author: Chen Weiqiang, GU Hong-standard, You-Ji Li, Huang Wei-Jun [Abstract] Objective To study the Han nationality in South China IgA nephropathy Fcα R1 gene 5 ‘end of regulation and the UTR area with SNPs and haplotypes in South China the relationship between the prognosis of patients with IgA nephropathy. Methods collected 266 cases of biopsy proven IgA nephropathy in patients with blood samples, extracted genomic DNA. Direct sequencing of PCR products with the identification of genotypes, every 3 to 6 months, check urine protein, serum creatinine, and other indicators for follow-up to the baseline serum creatinine concentration higher than 1 times or more, or death as the end of follow-up. Single factor correlation analysis and Logistic regression analysis of polymorphism and its Members haplotypes and impairment of kidney function and prognosis. Results (1) in the region haplotype pairs and -27,56 polymorphism and progress of renal function was significantly correlated; (2) -27 locus TC and TT genotypes was significant difference (P = 0.003); 56 Wei CC compared with TT genotype, P = 0.011; haplotype pairs of TCC / CTC and TTT / TTT comparison, P = 0.000. Conclusion Fcα R1 gene first exon of polymorphic loci C56T genotype and prognosis in patients with IgAN in southern China. [Keywords:] IgA nephropathy; Fcα R1 gene; polymorphism; Prognosis; correlation analysis Abstract: Objective To investigate the relationship between the prognoses and the polymorphisms of Fcα R1 gene in Chinese Han IgA nephropathy (IgAN) patients in the South China.Methods 266 blood samples from renal  biopsies that had been proven IgA nephropathy were collected, the genotypes were determined by PCR product sequencing.All patients were followed up every 3 to 6 months by examining urinary protein, Scr, and other indicators.Fo