Fluorouracil suppository combined with radiotherapy for locally advanced rectal cancer in elderly clinical observation.docVIP

 PAGE \* MERGEFORMAT 15 Fluorouracil suppository combined with radiotherapy for locally advanced rectal cancer in elderly clinical observation [Abstract] Objective To observe the bolt fluorouracil combined with radiotherapy for locally advanced non-surgical treatment of elderly cancer efficacy and adverse reactions. Methods 46 elderly patients with pathologically confirmed locally advanced inoperable rectal cancer patients receiving fluorouracil embolism anal, 200 mg / tablets, 2 times / d, used in conjunction 10 d.24 d as a cycle, shared two cycles. earlier received pelvic three-dimensional conformal radiotherapy, 46 ~ 50 Gy/23 ~ 25F, reduced fields to the tumor area after continuing to push the amount to 64 ~ 66 Gy / 32 ~ 33F, if residual disease is the line brachytherapy 15 ~ 20 Gy. Results CR 18 (39.1%), PR 23 (50.0%), SD5 (10.9%), the total effective rate (CR + PR) 89.1 %, the median survival time of 21.6 months, 1,2-year survival rates were 87.4%, 71.9%. the major treatment-related side effects were diarrhea and neutropenia, well tolerated by patients with symptomatic treatment. Conclusion fluorouracil thrombectomy radiotherapy for locally advanced non-surgical treatment of elderly rectal cancer is safe and effective, is worthy of further study. [Keywords:] with locally advanced; cancer; fluorouracil suppository; radiotherapy [Abstract] Objective To observe the effect and toxicity of fluorouracil suppository and concurrent radiotherapy in elderly local advanced rectal cancer.Methods Forty-six elderly patients with ocal advanced rectal cancer were treated with 200 mg fluorouracil suppository by rectum, twice a day, for 10 days, a 24-dat cases of treatment, two cases of the treatment and combination with three dimensional-conformal radiotherapy (for46 ~ 50 Gy/23 ~ 25F and was boosted to the tumor 16 ~ 18Gy / 2 weeks, 2Gy/fraction, 5 days / week). Intra-rectal cavity radiotherapy with 15 ~ 20 Gy for the residual lesion.Results The overall res