Flurbiprofen on laparoscopic myomectomy in patients with analgesic effect and platelet aggregation.docVIP

 PAGE \* MERGEFORMAT 8 Flurbiprofen on laparoscopic myomectomy in patients with analgesic effect and platelet aggregation Of: Zan Lily, Jin Xin, Ji Fuhai, Yang Jianping [Keywords:] flurbiprofen; epoxide inhibitors; postoperative pain; pain Analgesic effect of opioids precise, but easy to cause nausea and vomiting, abdominal pain, constipation, dizziness, drowsiness, urinary retention, pruritus, respiratory depression and other adverse reactions. Flurbiprofen using Lipo technology to make wrapped together inside the drug targeting and inflammation in the surgical incision site, and can rapidly across the cell membrane and continuous release of [1], the postoperative pain and has some advantages. The main purpose of this study is to flurbiprofen Laparoscopic myomectomy for patients to observe the effect of postoperative analgesia as well as platelet aggregation (platelet aggregation, PAG) of. 1 Subjects and methods 1.1 disease cases This test by the hospital ethics committee approval and informed consent of patients obtained. A randomized double-blind control study, laparoscopic myomectomy selected a total of 30 patients were randomly divided into 2 groups, each group had 15 patients aged 20 to 65 years old, ASA ~ grade level. 1.2 Exclusion criteria Bleeding tendencies; a history of blood system diseases; a history of peptic ulcer; severe liver and kidney dysfunction; patients with severe heart disease; a history of severe hypertension. 1.3 Anesthesia All patients were treated with total intravenous anesthesia. Anesthetic induction: midazolam 0.5 mg / kg, propofol 0.15 mg / kg, fentanyl 2.5 g / kg, succinylcholine 1.5 mg / kg assisted endotracheal intubation, intubation and then given vecuronium 0.1 mg / kg to maintain muscle relaxation. Anesthesia was maintained: intravenous infusion of propofol (4 mg kg-1 h-1), remifentanil (0.15 g kg-1 min-1) to maintain anesthesia, tidal volume of 8 ~ 10 ml / kg. intraoperative completion o