Huang Shan ORTHOGONAL prescription oral patch.docVIP

 PAGE \* MERGEFORMAT 14 Huang Shan ORTHOGONAL prescription oral patch Of: Zhang Shu, Deng Hong, Lin Huaqing, Liu Na [Abstract] Objective To prepare for the treatment of oral ulcers mountain yellow oral patch. Approach to oral patch adhesion, drug release rate as the index, the orthogonal experiment, screening prescription oral patch. The results screen has been optimized prescription are: microcrystalline cellulose, starch and the mass ratio of 3:2, HPMC (K15M CR dosage is 15%. Mount Huang Fang extracted some herbs have dried extract powder, powder and other herbs to join the Fang accessories to the volume fraction of 70% ethanol as wetting agent, wet granulation and tablet, film coated side of anti-sticking layer. The in vitro adhesion and release rate than ideal. Conclusion The mountain yellow filter prescription oral patch stable and feasible. [Keywords:] Shan Huang orthogonal patch adhesion of oral drug release rate Abstract: Objective To optimize the formulation of Shanhuang oral mucoadhesive patch. Methods According to the index of the adhesion and drug release rate, orthogonal design was used to optimize the formulation. Results The optimized formulation was as following: After the material of Shanhuang were extracted , the other material powder, the mixture of starch and MCC (3:2) and 15% HPMC (K15M CRwere used as excipient to make granule, and then press to tablet. A water proof film was made on one side. The average adhesion and the drug release rate of the tablet were good. Conclusion The formulation was repeatable and reliable. Keywords:: Shanhuang oral mucoadhesive patch, orthogonal design, drug release rate Mountain yellow powder for clinical prescription, mainly by the artificial bezoar, borneol, berberine, tonkinensis etc., attending functions of detoxification, swelling pharynx. For lung and stomach caused by toxic heat flaming sore throat, mouth erosion embolism. As a special oral physiological environment for the treatment o