Human epigenetic disease mechanism and therapy.docVIP

 PAGE \* MERGEFORMAT 15 Human epigenetic disease mechanism and therapy [Keywords:] epigenetics; environment; treatment; human disease Watson and Crick discovered the double helix structure of DNA after 50 years, genetic engineering drugs in the treatment of human disease gradually take place, the completion of the Human Genome Project for the gene therapy has opened up more space. In recent years, emerging as the genetics Subject - Epigenetics in human disease treatment gained more and more evidence [1]. It reveals the complex from the molecular level of clinical phenomena, as unlock the mysteries of life and bring new hope to conquer disease. Epigenetics is the study of DNA sequence variation is not the case, the biological phenotype of genetic changes that can be a discipline [2]. Epigenetic genome to the apparent genetic modification, and the apparent modification, including: DNA methylation, histone modification, chromatin remodeling, X chromosome inactivation, genomic imprinting, regulation of non-coding RNA [3], any one of the disorders, may cause disease, including cancer, chromosomal instability syndrome and intellectual slow [4]. epigenetic change is reversible, which provides for the treatment of human disease optimistic outlook. This paper Biaoguan genetics and human diseases, the environment and the relationship between epigenetics and epigenetic treatment 3 were reviewed. An epigenetic modification and human disease 1.1 DNA methylation-related diseases DNA methylation refers to the DNA methyltransferase (DNMTs) in the catalyst, the methyl group transferred to a modified cytosine base on the way. It occurs mainly in the dinucleotide CpG island-rich region in the human genome has nearly 50,000 CpG islands [5]. normally is non-CpG island methylation in the form (active form) exist, DNA methylation can cause gene silencing. DNMTs activity anomaly closely related diseases, such as in the DNMT3B gene mutation on chromosome syndrome can