Increased eosinophil cell disease genetics research.docVIP

 PAGE \* MERGEFORMAT 19 Increased eosinophil cell disease genetics research Author: Zhang Yan, He Qi, HUANG Xiao, Jiang Hao, Yang Shen Miao, Lu Jin, Qin Ya-Qin, Shi Yan, Hui Dang, Jing-Ying Qiu, Dao-Pei Lu Abstract To study the cloning of chromosomal abnormalities in the eosinophil cell histiocytosis in the diagnosis and differential diagnosis of the meaning and clonal eosinophil cell histiocytosis involving chromosomal abnormalities, collected 65 cases of increased eosinophils in patients with bone marrow specimens, cultured for 24 hours, using G-banding karyotype analysis. The results showed that: 65 patients in 9 cases to be diagnosed as acute myeloid leukemia  M4Eo detection of specific chromosomal abnormalities inv (16), while the remaining 56 cases to an increase in eosinophils in patients with diagnosis to be detected in 5 cases Cloning of chromosomal abnormalities, the detection rate was 8.9%. Based on the clinical, hematological data and combining the results of chromosome detected in 5 patients were finally diagnosed as acute myeloid leukemia with increased eosinophils in chronic eosinophilic leukemia, 8p11 myeloproliferative syndrome, chronic myeloid leukemia CML , acute myeloid leukemia  M4Eo. Cloning of chromosomal abnormalities detected were 14, t (5; 12) (q31; p13), t (8; 9) (p11; q32), t (9; 22) (q34; q11) and inv (16) (p13q22). Conclusion: The increase in eosinophils in the diagnosis, the chromosome test is to determine cloning and diagnosis of chronic eosinophilic leukemia, an important means should be used as routine testing. Keywords: clonal eosinophil cell histiocytosis with chronic eosinophilic leukemia cytogenetic chromosomal abnormalities Cytogenetic Study on Eosinophilia Abstract The aim of study was to investigate the importance of chromosome aberration in differential diagnosis of eosinophilia and the chromosomal aberrations involved in patients with clonal eosinophilia. 65 cases of eosinophilia were