Insulin resistance in type 2 diabetes in the inflammatory mechanisms and Differential Diagnosis and Treatment.docVIP

 PAGE \* MERGEFORMAT 17 Insulin resistance in type 2 diabetes in the inflammatory mechanisms and Differential Diagnosis and Treatment [Abstract] the occurrence of type 2 diabetes and inflammation and development is closely related to, inflammatory cytokines can cause insulin resistance, insulin secretion dysfunction, inflammatory cytokines, including TNF  α , IL  6, CRP, adiponectin, MCP  1 and so on . Chinese medicine treatment of diabetes has extensive clinical experience, that the etiology and pathogenesis of insulin resistance and the spleen and stomach wasting related to herbal therapy regulate inflammatory state of diabetes and improve insulin resistance. [Keywords:] Type 2 diabetes mellitus / TCM therapy; insulin / pharmacodynamics; inflammation Type 2 diabetes mellitus (Type 2 diabetes mellitus, T2DM) The etiology and pathogenesis has not been fully clarified. In recent years, a large number of studies have shown that the occurrence of the development of T2DM and its complications are closely related with the inflammation, T2DM is a congenital immune and low-grade chronic inflammatory diseases. In the T2DM in susceptible individuals, with the aging and over-nutrition and other environmental factors, the role of innate immune system is activated, macrophages, fat cells, such as sentinel cells to secrete TNF  α , IL  6 and other inflammatory factors, thereby causing insulin resistance (insulin resistance, IR), insulin secretion dysfunction occurring. Chinese medicine treatment of diabetes has a wealth of clinical experience, and doctrine for the T2DM of chronic inflammation, diabetes prevention and treatment of Chinese medicine to carry out the research, will help to improve the clinical results and to clarify its mechanism of action. Existing studies have shown that, IR and insulin secretion dysfunction may not be independent of each other, if the role of insulin secretion determined from the case, then the islet β -cell IR seems to be a br