Med19 in human gastric carcinoma and its clinical significance.docVIP

 PAGE \* MERGEFORMAT 10 Med19 in human gastric carcinoma and its clinical significance Study: Phase Fu Ding Xuedong Huang Guomin Li Junan room [Abstract] Objective Med19 gene in human gastric carcinoma and clinical significance. Methods Immunohistochemistry and RT PCR to detect Med19 gene in gastric cancer, gastric cancer and adjacent normal gastric tissues. Results in gastric carcinoma of Med19 expression was 71.7% (43/60, significantly higher than in adjacent normal gastric tissue and gastric tissue (P lt;0.01. carcinomas and normal gastric mucosa adjacent to gastric tissue Med19 mostly negative expression, a small number of weakly positive, between the two was no significant difference (Pgt; 0.05.Med19 expression and cell differentiation of gastric cancer, lymph node metastasis, TNM staging (P lt;0.05), but in a different age, gender, tumor size, invasive depth of gastric cancer samples no significant difference in expression (Pgt; 0.05. Conclusion Med19 involved in gastric cancer, the development process, is expected to become a new cancer therapy targeting factors. [Keywords:] MED19, gastric cancer, gene expression The occurrence of gastric cancer and cancer gene mutation, amplification, overexpression, and mutations in tumor suppressor gene inactivation are closely related. Mediator subunit Med19 subunits of the homologous gene in human lung cancer metastasis-related genes LCMR1, the current few studies of its function. We observed the gastric Med19 protein and its relationship with clinicopathological features, of Med19 expression in gastric cancer occurrence and development of relevance. 1 Materials and methods 1.1 Object and reagents 60 cases of human gastric cancer tissue samples were obtained from general surgery in our hospital, including 36 males and 24 females, mean age 58.2 years, all the specimens were pathologically confirmed gastric adenocarcinoma, and none received preoperative radiotherapy and chemotherapy. Histology 20