Matrix metalloproteinases -9 and laminin in primary Sjogrens syndrome labial glands expression.doc

 PAGE \* MERGEFORMAT 10 Matrix metalloproteinases -9 and laminin in primary Sjogren’s syndrome labial glands expression [Abstract] Objective To study matrix metalloproteinase -9 (matrix metalloproteinase-9, MMP-9), laminin (Laminin, LN) in primary Sjogren’s syndrome (Primary Sj ?i grens’s Syndrome, PSS) of the salivary glands of patients expression and lip management grades of adenovirus. immunohistochemical SP method detected 59 cases of PSS, 30 patients with labial glands of normal controls MMP-9, LN expression. results in patients with primary Sjogren’s syndrome labial gland expression of MMP-9, LN low expression in the control group in the salivary glands of the low expression of MMP-9, LN high expression, MMP-9 expression intensity increased with the lips and is enhanced adenovirus reasonable classification, LN expression reasonable classification of lip increased with weakened adenovirus, MMP-9 expression and LN negative correlation. Conclusions MMP-9, LN in the PSS in the salivary glands of patients with abnormal expression and the expression of both tumor grade and related. [Keywords:] primary Sjogren’s syndrome matrix metalloproteinases -9 labial glands of laminin Abstract: Objective To study the relationship between MMP 9, LN and their roles in the pathogenesis of Primary Sj ?i grens’s Syndrome. Methods Immunohistochemical technique was employed to detect the expression of MMP 9 and LN in the labial gland acini of patients with Primary Sj ?i grens’s Syndrome (PSS). Results Significant differences in LN and MMP 9 expressions between two groups were found.The expression of MMP 9 in the labial gland of the patients with PSS was increased significantly (P lt;0.01) and the expression of LN in the labial gland acini of the patients with PSS was decreased significantly (P lt;0.01). The expression degree of MMP 9 was significantly negatively correlated with the the expressioned degree of LN, and the Pearson’s correlation coefficient was 0.997 (P lt;0