microRNAs and related progress in cancer research.doc

 PAGE \* MERGEFORMAT 6 microRNAs and related progress in cancer research [Abstract] microRNA (miRNA are a class of about 22 nucleotides non-coding small molecule RNA, mainly involved in regulation of gene transcriptional level, it completely with the target mRNA or incomplete pairing and promote target mRNA degradation or inhibition of protein translation. In recent years, a large number of miRNA and tumor-related have been found involved in the formation of a number of human tumor signaling pathways, miRNA also proposed as a potential target for cancer therapy. In this paper, the study of miRNA in cancer made latest reviewed. [Keywords:] miRNA small RNA tumor cancer therapy Advances of microRNAs in Cancer Research He Liu-yuan, Xu Xiao-hong. Medical Laboratory, Hefei Maternal and Child Health Hospital, Hefei 233000, China [Abstract] MicroRNA (miRNA), a kind of about 22 nucleotides non-coding small molecule RNA in length, which is mainly involved in post-transcriptional gene regulation, promotes target mRNA degradation or inhibits protein translation through complete or incomplete complementary pairing of mRNA . In recent years, a large amount of tumor-related miRNAs have been found and participate in multiple signal pathways of human cancer formation. Meanwhile, it is reported miRNA can be used as a potential target of cancer treatment. This review will present the advances of miRNA in cancer research. [Keywords:] MiRNA MicroRNA Cancer occurring Anti-tumor therapy Currently, miRNA is the current hot spot in the field of life science research, in 2002 and 2003 two consecutive years by Science magazine as the top ten scientific and technological breakthroughs. Research shows that, miRNA involved in regulating many biological processes in vivo, especially closely related to tumorigenesis. About miRNA miRNA are a class of small molecule single-stranded RNA, the length is about 21-25nt.miRNA itself does not have an open reading