Myasthenia gravis on rat diaphragmatic Morphology of motor end-plate.doc

 PAGE \* MERGEFORMAT 12 Myasthenia gravis on rat diaphragmatic Morphology of motor end-plate Author: Liu Rui Li Zhu 1 Qi Gui-Ping Wang Jin-ping Liu bow [Keywords:] myasthenia gravis Research on morphological changes of end plates in diaphragm of experimental autoimmune myasthenia gravis rats [Abstract] AIM: To study the pathological characteristics of the end plate on diaphragm in experimental autoimmune myasthenia gravis animal model by light microscopy and electron microscopy. METHODS: Passively transferred myasthenia gravis animal model was prepared by injection of acetylcholine receptor monoclonal antibody mAb35, and the ultrastructure of the end plates was studied by acetylcholinesterase histochemical technique. RESULTS: Myasthenia symptoms were induced in the experimental group. The end plates of diaphragm showed ultrastructural changes similar to those of myasthenia gravis patients but no change was found in the number of the end plates. No changes were observed in the control group. CONCLUSION: It is suggested that the ultrastructural changes of the end plates on diaphragm may result in the dyspnea in experimental autoimmune myasthenia gravis. [Keywords] myasthenia gravis; acetylcholinesterase; receptors, cholinergic; motor endplate; ultrastucture [Abstract] Objective: To investigate the myasthenia gravis on rat diaphragmatic motor end-plate light microscopy and electron microscopy of structural changes. Methods: Passive transfer of acetylcholine receptor monoclonal antibody mAb35 was the establishment of SD rat model of autoimmune myasthenia gravis with acetylcholine ester Enzymatic Show diaphragmatic motor end-plate, parallel ultrastructural observation. Results: The experimental group significantly after injection of mAb35 gravis symptoms, the number of motor end-plate diaphragm basically unchanged, but appears similar in patients with myasthenia gravis Advanced Micro Devices structural change in the control group had no significant change. Con