Nimesulide-induced drug rash one cases of scarlet fever-like.doc

 PAGE \* MERGEFORMAT 2 Nimesulide-induced drug rash one cases of scarlet fever-like [Keywords:] Nimesulide scarlet fever-like drug eruption A clinical data Children, female, 1 year 5 months due to ‘fever, poor feeding 2 d, rash 1 h’ hospital. Children in pre-hospital 2 d of fever, irregular type, body temperature up to 40.2 ℃ , no chills and chills, accompanied by salivation and Qing Ke, unwilling to eat. Since the clothes at home, ‘Roxithromycin’, is ineffective, heat reclaim. The day before admission to hospital outpatients diagnosed as acute upper respiratory infection, outpatient prescription Cefixime, Houttuynia, nimesulide (Switzerland Pollock, Hainan Sino-Swiss Kangzhi Pharmaceutical Co., Ltd., batch number 080603) in the treatment . After returning home because of fever, only the clothes Nimesulide 25 mg, 20 min after the trunk and buttocks skin rash, accompanied by tickle, 30 min after spreading into the film, showing the distribution of the non-symmetry. Since the incidence of poor appetite, no abdominal pain, diarrhea and nausea, vomiting, non-asthma and seizures, urine normal. Customarily physical health, no history of allergies. Examination: body temperature 38.4 ℃ , breathing 40 times / min, pulse 130 times / min, weight 10 kg. Development of normal, well-nourished, acute heat sickly look, trunk and buttocks visible diffuse cutaneous flushing, which have a uniform, dense sample size of the red miliary rash, hand-press can be dissipated to the press after the rash does not subside between the skin rash normal, non-scaling, exudation. Whole body skin and no bleeding. Superficial lymph nodes are not touched. Anterior fontanelle has closed, rosy lips, perioral skin, no pale, clear throat congestion, Ⅰ ° swollen tonsils, lungs breathing sound thicker, no smell, and wet and dry nature of rales, heart, abdomen no abnormalities. Limbs, muscle strength, muscle tension normal. Assistant examination after admission showed: WBC 9.23 * 109 / L, L 52%, N