Ning Chinese rheumatoid joints of rats with adjuvant arthritis synovial tissue expression of ICAM 1.docVIP

 PAGE \* MERGEFORMAT 11 Ning Chinese rheumatoid joints of rats with adjuvant arthritis synovial tissue expression of ICAM 1 Of: Huang Ying Zeng Jie Ping Zhang Genghao [Abstract] Objective: To study the traditional Chinese medicine rheumatoid Ning (FSN) in experimental rheumatoid arthritis (RA) and mechanism of the effect. Methods: Adjuvant arthritis (adjunvant arthritis, AA) rats as experimental subjects, be, respectively, and the TWP FSN (TWP) for treatment, joint swelling degree of control rats, and intra-articular pathological changes. using immunohistochemistry to detect the AA rat synovial tissue lesions of ICAM 1 expression. Results: FSN AA significantly inhibited rat paw swelling, synovitis significantly reduce the disease and proliferative lesions to prevent the destruction of articular cartilage and bone; FSN can significantly reduce ICAM 1 in AA synovial tissues ( P lt;0.01) Conclusion: FSN has the improvement of RA symptoms and disease in experimental role, function and regulation of the inflammatory cells of synovial cells and cell adhesion between the extracellular matrix effects. [Keywords:] rheumatoid Ning; adjuvant arthritis; cell adhesion molecule 1 (ICAM 1) Rheumatoid arthritis (Rheumatoid arthritis, RA) is a common disease mainly in synovial autoimmune disease [1]. As complex RA pathology, pathogenesis, but also not yet clear, clinical treatment very difficult. Many studies have shown that Chinese medicine has some advantages against RA, RA anti-inflammatory and analgesic effects of Chinese medicine in addition, it also has immunomodulatory effects, showing overall conditioning, multi-link, multi-pathways [2]. In this study, CFA adjuvant-induced adjuvant arthritis (Adjuvant arthritis, AA) rats as animal models of RA, observed Professor Wang Zaimo clinical experience side - rheumatoid Ning (FSN) the role of RA treatment characteristics, and by detecting synovial tissue in rats ICAM 1 expression, the mechanism of anti-inflammatory e