NMDA-dependent synaptic long-term potentiation and long-term depression model and simulation.docVIP

 PAGE \* MERGEFORMAT 14 NMDA-dependent synaptic long-term potentiation and long-term depression model and simulation Authors: Dong Ai-Rong, TAN Xiao-Dan, Su Yongchun, GAO Tian-ming, DENG Qin-kai [Keywords:] long-term potentiation A model and simulation research of NMDAdepended bidirectional synaptic plasticit [Astract] AIM: To study the correlative mechanism between the induction of long term modification and the activity of different NMDA receptor subtypes. METHODS: Based on the analysis of dynamic properties of NMDA receptor subtypes, an amended mathematical model of postsynaptic calcium was proposed to describe the relationship between different NMDA receptor subtype activity and presynaptic stimulus frequency. Along with a biochemicalreaction networks model of the postsynaptic Ca2 depended signaling pathways, we developed a unified biophysical model about the hippocampal CA3CA1 synapses bidirectional plasticity. RESULTS: According to the inductive condition of longterm potentiation (LTP) and long term depression (LTD), our computer simulation mimicked the induction processes of NMDARdependent long term modification. CONCLUSION: It is elucidated that the calcium transients required for LTD may primarily come from the calcium inflow mediated by NR2B subtype channel of NMDA receptor and the induction of LTP may require the calcium inflow mediated by NR2B subtype channel. [Keywords] longterm potentiation; longterm depression; receptors, NmethylDAspartate; biophysical model [Abstract] Objective: To investigate the synaptic long-term potentiation and long-term depression and NMDA receptor subtypes in the correlation between the activity of the state. Methods: Based on the NMDA receptor channel subtype differences in characteristics of the dynamic analysis, propose a amended postsynaptic calcium signal model to describe the activity of different subtypes of NMDA receptor status and the relationship between the frequency of presynaptic stimulation, combined w