Nude mouse model of human colon cancer and its clinical 1.5TMR imager 1H-MRS study.doc

 PAGE \* MERGEFORMAT 16 Nude mouse model of human colon cancer and its clinical 1.5TMR imager 1H-MRS study [Abstract] Objective To explore the clinical medical 1.5T MR imager on the nude mouse model of human colon cancer with conventional MR imaging and proton MR spectrum (1H-MR spectroscopy, 1H-MRS analysis of the possibilities. Methods SW480 human colon cancer block planted in 25 nude mice under anesthesia into nude mice bearing human colon cancer ectopic. tumor-bearing mice given OK MR T1WI, T2WI, 1H-MRS scan, and compared with pathological findings. Results 25 nude mice were tumor. T2WI images can clearly show the tumor, the tumor signal and muscle T1WI, T2WI high signal, the central necrotic area is only .18 higher signal single element mouse MRS acquisition success, 22 more than two-dimensional voxel acquisition success, 25 successful three-dimensional multi-voxel acquisition. Conclusions and Clinical Medical Clinical Medical 1.5TMR coil model is feasible for human colon cancer xenografts 1H-MRS study, conventional MRI T2WI image can reflect the pathological changes in transplanted tumors, the results more easily reflect the clinical features of human disease. [Keywords:] nude new biological colon Proton MR spectrum magnetic resonance imaging [Abstract] Objective To investigate the feasibility of MR T1WI, T2WI and 1H-MR spectroscopy (1H-MRSwith clinical 1.5T scanner in vivo in a xenotransplant nude mouse model with human colon carcinoma. Methods The tumor pieces of human colon cancer SW480 were implanted subcutaneously in 25 nude mice. These mice were scanned with TSE-T1WI, T2WI and 1H-MRS and MR images were compared with histopathological findings. Results The subcutaneous tumors grew in 25 mice. All tumors were detected clearly on T2WI images, and shown as iso-intensity as muscle on T1WI and hyper-intensity on T2WI in which more hyper-intensity in necrotic areas. 1H-MRS were satisfactory for 18 mice with single voxel, 22 mice with 2-demensional