Of mild hypothermia on secondary brain injury protective effect of the progress.docVIP

 PAGE \* MERGEFORMAT 3 Of mild hypothermia on secondary brain injury protective effect of the progress [Keywords:] brain injury secondary hypothermia 0 Introduction Traumatic brain injury (traumatic brain injury, TBI) accounts for all parts of the body’s first two injuries, case-fatality rate was 30% ~ 50% [1], ranking No. 1. Because of injury deaths in China each year about 10 million people who injured millions of people, and with the development of the society gradually increase. In the United States, traumatic brain injury is the main cause of death in each of the 10 million people died from injuries in about 50% was due to head injury caused. TBI not only damage occurred in an instant, and thereafter took place a few minutes to several days, referred to as secondary brain injury (SBI). mild hypothermia can reduce the metabolic rate of the organization to reduce the nerve tissue of brain injury such as edema secondary brain injury . we are of mild hypothermia (MHT) on the secondary brain injury in the role of review and outlook. 1 Overview Early in the 20th century, 50’s, low temperature had been used in cardiovascular surgery in order to protect the brain and other vital organs, but because of congestive heart failure, ventricular fibrillation, and coagulation disorders, severe complications were abandoned, only selected sex for some complex cardiovascular surgery. the 20th century, the late ‘80s, the International will be divided into mild hypothermia hypothermia (mild hypothermia): 33 ~ 35 ℃ ; moderate hypothermia (moderate hypothermia): 28 ~ 32 ℃ ; profound hypothermia (profound hypothermia): 17 ~ 27 ℃ ; ultra-deep hypothermia (ultraprofound hypothermia): 16 ℃ below, the former two is defined as the MHT. 20 centuries since the 90s, MHT on ischemic and traumatic brain injury in the brain protection has once again aroused the attention of scholars abroad. clinical study found that 30 ~ 33 ℃ MHT can significantly reduce the mortality rate in patien