Oxaliplatin combined with chemotherapy in the treatment of gastric cancer care.docVIP

 PAGE \* MERGEFORMAT 6 Oxaliplatin combined with chemotherapy in the treatment of gastric cancer care [Keywords:] Oxaliplatin Oxaliplatin is a third generation of the clinical use of platinum anticancer drugs, their hydration in the body by producing derivatives acting on the deoxyribonucleic acid (DNA), the formation of DNA chain and cross-linking between chains, thus inhibiting DNA - synthesis, resulting in cytotoxicity and anti-tumor activity, domestic and international clinical studies have shown that oxaliplatin has significant effects on the digestive system cancer in clinical practice often used in digestive tract cancer fluorouracil combined treatment with the drug in the course of the Central Standing Committee made a number of side effects, the need for special care [1], our hospital from June 2002 to June 2006 the use of oxaliplatin and folinic pyrimidine fluoride gland CF (CF) in the treatment of advanced gastric cancer 58 cases of clinical care will now be reported as follows. A clinical data 1.1 General Information 58 patients in this group were 37 males and 21 females; aged 32 to 75 years old. 16 cases of liver metastasis, lymph node metastasis in 20 cases, lung metastasis in 5 cases, after surgical treatment of 41 cases, kps score ≥ 70 points, blood and liver and kidney function was normal. 1.2 Methods Oxaliplatin 130mg/m2 in 5% glucose injection 500ml of intravenous infusion (1st day), CF 200mg/m2 intravenous infusion of normal saline (1 ~ 5 days), 5 - fluorouracil 500mg/m2 in 5% glucose intravenous injection (No. 1 ~ 5 days), intravenous infusion of the use of dark bags and dark infusion. 2 Results Main side effects during chemotherapy are nausea, vomiting, sensory nerve toxicity, oral mucositis, bone marrow suppression and so on, symptomatic treatment to alleviate. Mood, renal dysfunction, the patient can tolerate the successful completion of chemotherapy, and in Table 1. Table 1 main side effects during chemotherapy (omitted) 3 Ca