Panax notoginseng saponins on hepatic fibrosis in mice serum transforming growth factor.docVIP

 PAGE \* MERGEFORMAT 6 Panax notoginseng saponins on hepatic fibrosis in mice serum transforming growth factor Author: Yu Wan-gui, ZHANG Heng-wen, HE Shangrong, Anchor in the spring [Keywords:] 37 Abstract: Objective To observe the Panax notoginseng saponins on hepatic fibrosis in mice IL1 serum TGFβ 1 and explore the effect of Panax notoginseng saponins on hepatic fibrosis may be the immunological mechanism. Methods CCl4 toxicity of replication in mice model of liver fibrosis, while giving the treatment of PNS, enzyme-linked immunosorbent assay (ELISA) in serum levels of TGFβ 1 and IL1, parallel detection of liver biopsy pathology. The results of PNS can significantly reduce the serum of mice with liver fibrosis TGFβ l and IL1 levels, reduce the degree of liver fibrosis. Conclusion of PNS with anti-hepatic fibrosis and its mechanism may be related to lower serum levels of IL1 in TGβ p1 and relevant. Keywords: Panax notoginseng; liver fibrosis; transforming growth factor β 1; interleukin-1; Mice Effects of Panax notoginseng Saponins on TGFβ 1 and IL1 in Mice Serum with Liver Fibrosis Abstract: Objective To observe effects of Panax notoginseng saponins (PNS) on TGFβ 1 and IL1 of serum in mice with 1iver fibrosis.MethodsThe model of CCl4 induced liver fibrosis was established in mice and they were treated with PNS.Serum 1evel of TGFβ 1 and IL1 were determined and observed tissue patho1ogy.ResultsIt significantly decreased 1evel of TGFβ 1 and IL1 in serum with PNS treatment, and the 1iver fibrosis was improved.Conclusion PNS has reversal effects on mice with hepatic fibrosis, it may be correlated with drop serum level of TGFβ l and IL1 . Keywords:: Panax notoginseng Saponins; Hepatic fibrosis; TGFβ 1; IL1; Mice Chinese medicine, the liver fibrosis is mainly caused by Qi stagnation blood stasis, the use of blood circulation drug treatment. 37 strong, the power not only nutritious, but also blood circulation of the main drug. Studies have shown that Panax