Pigment epithelium derived factor and choroidal neovascularization.docVIP

 PAGE \* MERGEFORMAT 20 Pigment epithelium derived factor and choroidal neovascularization Of: Han Yuan Hui, Xie Bolin, Jian-Yu Yang, Jiang Lei [Abstract] pigment epithelium derived factor (pigment epithelium derived factor, PEDF) is a secreted protein, relative molecular weight of 50,000, is a member of the superfamily of serine. In recent years a large number of studies found that PEDF has a variety of biological effects, including anti- neovascularization, neurotrophic and neuroprotective. PEDF is the most effective inhibitor of endogenous ocular neovascularization. PEDF for the treatment of vascular proliferative diseases and retinal degenerative diseases and has broad prospects for PEDF in recent years on research progress and and choroidal neovascular diseases, give review progress in the study. [Keywords:] pigment epithelium derived factor; choroidal neovascularization Abstract Pigment epithelium derived factor (PEDF) is a relative molecular weight 50000 secreting protein and a member of the serp in super family. Recent studies demonstrated that PEDF has multiple biological functions , including antiangiogenic, neurotrophic and neuroprotective properties. It has recently been shown that PEDF is the most potential endogenous inhibitor of angiogenesis in eyes. PEDF has a wide prospect for treatment of human neovascular diseases and retinal degenerative diseases. Finding of PEDF brings new hope for treatment of neovascular diseases. Research progresses in PEDF and the relations between PEDF and choroidal neovascular diseases are reviewed. ?r KEYWORDS: pigment epithelium derived factor; choroidal neovascular diseases 0 Introduction Pigment epithelium-derived factor is equal to the Tombran Tink first discovered in 1989, and from the secretions of fetal retinal pigment epithelial cells in the initial isolated by ion exchange. PEDF is a protein molecular weight of 50,000, is a serine protease inhibitor does not inhibit superfamily me