Pig Simultaneous pancreas-kidney transplantation in rats.doc

 PAGE \* MERGEFORMAT 12 Pig Simultaneous pancreas-kidney transplantation in rats Author: Cheng-You Wang Yong Ni ZHAN Yong-qiang LIANG Hao-hui Zheng Ya-Xin Xu Xianzhong WONG Chi Hang [Abstract] Objective: To explore the simultaneous pancreas-kidney transplant surgical methods and techniques. Methods: 6 pairs of pigs over the same period pancreas-kidney transplantation (SPK), use of donor duodenum and recipient jejunum end to side anastomosis to establish pure pancreatic juice drainage (ED). Postoperative monitoring of pancreatic endocrine function, pancreatic secretion and renal function. Results: 6 pairs of pigs were successfully used in surgical SPK ED completed a simultaneous pancreas-kidney transplantation, survived up to five cases of receptor in January, their blood glucose levels gradually returned to normal kidney function. Conclusion: SPK + ED can be effectively applied to type 1 diabetes and renal failure treatment, as long as the master of skilled surgical techniques and operations, can be simultaneous pancreas-kidney transplantation as a therapy of choice. [Keywords:] pancreas-kidney transplantation; diabetes; renal failure; surgical techniques 〔 Abstract〕 Objective To explore the operation modules and surgical techniques of pancreas-kidney transplantion. Methods Simultaneous pancreas-kidney transplantation (SPK) was carried out on 6 couples of pigs. Enteric drainage (ED) was adopt to discharge pancreatic fluid by a simple end-to-side anastomosis of donor duodenum to receptor jejunum. The pancreatic endocrine and exocrine functions and renal functions were monitored. Results Operations of SPK ED were successfully finished on 6 couples of pigs. 5 receptors lived over 1 month, and each gradually obtained a normal blood sugar without external insulin and a functional kidney. Conclusion SPK ED could effectively be applied as the optimized therapy for type 1 diabetes with renal failure. Essential surgical techniques and versed manipulation should be