Progress in anti-tumor mechanism of curcumin.docVIP

 PAGE \* MERGEFORMAT 13 Progress in anti-tumor mechanism of curcumin [Keywords:] Summary of anti-tumor effect of curcumin Turmeric (Curcuma longa) Turmeric is the rhizome of the ginger family of plants, mainly produced in China, India, Japan and other countries. Turmeric, not only in India as a curry spice used in food, but also in China has a long medicinal history, their sexual Weixin , bitter, warm, practical gas Po Yu, pass through the pain. turmeric curcumin main components of a wide range of pharmacological effects, and for anti-tumor effect of curcumin, has long focused on the chemical prevention of tumor. With modern molecular the continuous development of biological research, the researchers on the mechanisms of curcumin a deeper study. The author has so far related to the antitumor effect of curcumin and its molecular mechanisms are reviewed. 1 inhibited tumor cell proliferation and induced apoptosis of tumor cells Curcumin has a variety of cytotoxic effect of tumor cells can inhibit tumor cell growth and induced apoptosis. Angle [1] Observation of curcumin on various tumor cells and morphological changes under light microscopy found that, 60 μmol / L curcumin could inhibit liver cancer cells (SMMC-7721), cervical carcinoma cell (Hela), colon cancer cells (SW480), erythroleukemia cells (K562), tongue cancer cells (Tca-8113), T lymphoma cells (Jurkat) cell proliferation and induced morphological changes in the corresponding. curcumin cytotoxicity and its inhibition of this nuclear factor κB (nuclear factor kappa B, NF-κB) transcription factors to affect cell signaling pathways. In addition, curcumin also by regulating the transcription factors AP, mitogen-activated protein kinase, growth factor receptor kinase and epoxy synthase and other means of cell proliferation. Curcumin induced apoptosis of tumor cells in vivo and in vitro by inhibiting the Akt/mTOR/p70S6K and activation of ERK1 / 2 signaling pathway and promote autolysis of malig