Progress in cell therapy of spinal cord injury.docVIP

 PAGE \* MERGEFORMAT 19 Progress in cell therapy of spinal cord injury Of: Liuming Yong, Zhao Jianhua, Wang Aimin [Abstract] spinal cord injury (SCI) often leads to devastating neurological disorder, is one of the hot. In recent years, stem cell transplantation for treatment of the cells represented in the SCI has made #8203;#8203;great progress, this paper, spinal cord injury Progress in cell therapy. literature shows, SCI is a multi-stage, multi-factor involved in the pathological process, the ultimate solution may lie in using a variety of methods combination of treatment strategies, including stem cell transplantation, to reduce glial scar, clear inhibitory molecules, the immune regulation and tissue engineering scaffolds such as bridge damage zone, and stem cell transplantation and immune regulation intervention SCI is one of the ways anticipated. And how in spinal cord tissue to create an environment conducive to the survival of neuronal stem cell differentiation in the microenvironment how to timely regulation of immune intervention will likely be the main direction of future research. [Keywords:] spinal cord injury; cell transplantation; stem cells; dendritic cells Abstract: Spinal cord injury (SCI) usually results in devastating neural dysfunction, thus it has been a research focus for many years.In recent years, significant progresses have been achieved in cell therapy for SCI, especially by strategies of neural stem cells (NSCs ) and dendritic cells (DCs) transplantation.By reviewing literatures, it’s concluded that SCI is a pathological process involving multiphases and multiple factors, and maybe its resolution depends on a combined therapeutic strategy, including stem cells transplantation, reduction of glial scar, clearance of inhibitory factors, immunoregulation and bridging the lesion using tissue engineering scaffold.Nevertheless, the strategy using NSCs combined with immunoregulation may be one of the most promising approaches, an