Progress in the treatment of toxoplasmosis.docVIP

 PAGE \* MERGEFORMAT 18 Progress in the treatment of toxoplasmosis Author: Cuiping, Wan-Hong Jiao, SONG Xian-ring Keywords: Toxoplasmosis;,, treatment;, research progress Keywords:: Toxoplasma gondii; treatment; Research Toxoplasma gondii (Toxoplasma gondii) called Toxoplasma gondii, is a real head coccidia, Toxoplasma Division. 1908, French scholar Nicolle and Tunisia in North Manceaux a rodent just to comb-toed mice liver and spleen mononuclear cells was found because trophozoites arched, so named Toxoplasma gondii [1]. Pest spread around the world, and the crowd a wide range of infections in many countries the infection rate at 25% ~ 50%, Europe up to 80% in some developed countries, China 5% ~ 10% [2]. Toxoplasmosis can cause a wide range of human-animal damage to the immune suppressed individuals and pregnant women, toxoplasmosis can cause serious consequences, is also one of the causes of death in patients with AIDS. Thus, the study of toxoplasmosis treatment has become the focus of domestic and foreign scholars, but also the issues at stake, this article about recent research in this area are reviewed. A western medicine therapy At present, the clinical treatment of toxoplasmosis is still the traditional sulfadiazine and pyrimethamine-based combination therapy. As early as 1988, Chang H. R et al [3] started physical appearance Chae Qi ADM role of anti-Toxoplasma gondii, followed Huskinson (1991), and Derouin (1992) [4,5] further proved that this drug on various types of Toxoplasma gondii trophozoites and cysts are killing effect, and the combination with pyrimethamine or sulfadiazine have a good synergy. China in 1998 by the Saudi Red [6] reported the first case of azithromycin in treatment of acute cases of toxoplasmosis. He Aizhen, etc. [7] in 1999 reported Azithromycin combination therapy with interferon results. Ding Zhen Ying et al [8] applied azithromycin, cotrimoxazole, interferon plus vitamin B complex and vitamin