Propofol on NMDA receptors in hippocampal CA1 area inhibit excitatory neurons injury mediated by.docVIP

Propofol on NMDA receptors in hippocampal CA1 area inhibit excitatory neurons injury mediated by 【Abstract】 Objective: NMDA receptor is the major excitatory central nervous system neurotransmitter-gated ion channels, receptors, but NMDA receptor is an intravenous anesthetic propofol anesthesia the molecular target site is currently surviving in the larger controversy and disagreement. To this end we use the whole braking conscious rat model, choose the hippocampal CA1 area damage of neurons (NENs) as an object of study, in vivo observation of the effects of propofol on spontaneous discharges of NENs influence to determine the NMDA receptor in which the role might be mediated. Methods: To establish a rat model of the whole conscious braking to identify and select the hippocampal CA1 area damage of neurons (NENs), that is, to noxious stimulation in the peripheral (with toothed forceps clamp the ipsilateral hind limb of rat skin) promptly after discharge the increase in neurons in cell LONDON physiological recording. Drug propofol and NMDA receptor antagonist (MK801) were used systemic administration of intravenous or line medial septal nucleus of local micro-injection administration were observed before and after administration NENs changes in spontaneous discharge. Results: A total of 24 recorded injury to hippocampal CA1 area of excitatory neurons (NENs), based on average discharge rate of 31.9 1