Qingpi on acute carbon tetrachloride liver injury in dose-effect relationship.docVIP

 PAGE \* MERGEFORMAT 6 Qingpi on acute carbon tetrachloride liver injury in dose-effect relationship Author: Jin Jing, Zheng Cao, Lin, Luo-sheng, LIU Quan-Zhi, Liu Qin [Abstract] Objective To observe the different doses of Qingpi decoction of carbon tetrachloride (CCl4) liver damage effects. Methods 40 rats were randomly divided into 5 groups, namely normal control group, model control group and Qingpi decoction of high, medium and low-dose treatment groups, respectively, intraperitoneal injection of equal volume of saline, saline, and Qingpi decoction (0.6 g / ml, 0.4g/ml, 0.2g / ml). Continuous 6d, 1 times / d. After the last administration, in addition to the normal control group injected with normal saline, the other rats were injected CCl4 dope a time, copy the rats with acute liver injury model, detection of serum alanine aminotransferase (ALT), aspartyl acid aminotransferase (AST) activity and liver tissue obtained for pathological examination. The results of different doses of Qingpi decoction could significantly reduce the CCl4-induced serum ALT and AST activity increased, and showed a clear dose-effect relationship. Qingpi decoction rat liver tissue degeneration and the extent of necrosis compared with the model group significantly reduced. Conclusion Qingpi decoction on CCl4-induced acute liver injury with a significant protective effect and dose-effect relationship. [Keywords:] Qingpi acute liver injury Protective effect of liver Abstract: ObjectiveTo observe the effcets of different doses of citri reticulatae viride decoction on CCl4-induced acute liver injury in rats.Methods40 wistar rats were randomly divided into four groups, namely the normal control group, the model control group, the high, media and low dose treating groups of citri reticulatae viride decoction. They were injected intraperitoneally with physiologic saline and citri reticulatae viride decoction (0.6g/ml. 0.4g/ml and 0.2g/ml) once daily for six days respectively. After the